For .NET 2.0, consider using Microsoft.Win32.SafeHandles.SafeFileHandle instead. It can be used where IntPtr is used. If you use a SafeFileHandle, do not call CloseHandle as the CLR will close it for you (even if it's already closed).

        return CreateFileMapping(File.SafeFileHandle.DangerousGetHandle(), IntPtr.Zero, flProtect, Hi, Lo, lpName);

        return CreateFileMapping(File.SafeFileHandle.DangerousGetHandle(), IntPtr.Zero, flProtect, Hi, Lo, lpName);

        Microsoft.Win32.SafeHandles.SafeFileHandle hDevice,

    ByVal hDevice As Microsoft.Win32.SafeHandles.SafeFileHandle, _

    SafeFileHandle hDevice,

   IntPtr fileHandle=f.SafeFileHandle.DangerousGetHandle();

static extern bool FlushFileBuffers(SafeFileHandle hFile);

static extern bool GetCommModemStatus(SafeFileHandle hFile, out uint lpModemStat);

Get the SafeFileHandle from call to CreateFile

    static extern SafeFileHandle CreateFile(string lpFileName, uint dwDesiredAccess,

    Private Shared Function CreateFile(ByVal lpFileName As String, ByVal dwDesiredAccess As System.UInt32, ByVal dwShareMode As System.UInt32, ByVal lpSecurityAttributes As IntPtr, ByVal dwCreationDisposition As System.UInt32, ByVal dwFlagsAndAttributes As System.UInt32, ByVal hTemplateFile As IntPtr) As Microsoft.Win32.SafeHandles.SafeFileHandle

static extern bool SetCommBreak([InAttribute] SafeFileHandle fileHandle);

            SetFileInformationByHandle(fileStream.SafeFileHandle, FileInformationClass.FileDispositionInfo, ref FileInformation, Marshal.SizeOf(FileInformation.FILE_DISPOSITION_INFO));

     SafeFileHandle hFile, long liDistanceToMove,

     SafeFileHandle hFile, long liDistanceToMove,

In the Microsoft .NET Framework version 2.0, you should use a SafeFileHandle instead of an IntPtr to refer to hNamedPipe.

  static extern bool SetNamedPipeHandleState(SafeFileHandle hNamedPipe, IntPtr lpMode,

    ByVal hNamedPipe As SafeFileHandle, _

public static extern int NtCreateFile(out SafeFileHandle handle, FileAccess access, OBJECT_ATTRIBUTES* objectAttributes, IO_STATUS_BLOCK* ioStatus, ref long allocSize, uint fileAttributes, FileShare share, uint createDisposition, uint createOptions, IntPtr eaBuffer, uint eaLength);

        out  Microsoft.Win32.SafeHandles.SafeFileHandle handle,

Microsoft.Win32.SafeHandles.SafeFileHandle hFile;

   out SafeFileHandle DirectoryHandle,

   SafeFileHandle h;

   out SafeFileHandle LinkHandle,

   SafeFileHandle h;

   SafeFileHandle DirectoryHandle,

    static extern IntPtr NtQueryInformationFile(SafeFileHandle fileHandle, ref IO_STATUS_BLOCK IoStatusBlock, IntPtr pInfoBlock, uint length, FILE_INFORMATION_CLASS fileInformation);

                IntPtr iprc = NtQueryInformationFile(fs.SafeFileHandle, ref iosb, p_fbi, (uint)Marshal.SizeOf(fbi), FILE_INFORMATION_CLASS.FileBasicInformation);

   SafeFileHandle LinkHandle,

     SafeFileHandle hFile,

For .NET versions prior to 2.0, replace SafeFileHandle with IntPtr

SafeFileHandle invalidHandle = new SafeFileHandle(new IntPtr(-1), true);

     if (IsCatalogFile(fs.SafeFileHandle, null))

    MiniDumpWriteDump( GetCurrentProcess(), GetCurrentProcessId(), file.SafeFileHandle.DangerousGetHandle(), MiniDumpWithFullMemory, ref info, IntPtr.Zero, IntPtr.Zero );

static extern Boolean HidD_FlushQueue(SafeFileHandle HidDeviceObject);

Declare Function HidD_FlushQueue Lib "hid.dll" (SafeFileHandle HidDeviceObject) As Boolean

    internal HIDP_CAPS GetDeviceCapabilities( SafeFileHandle hidHandle )

static extern Boolean HidD_GetFeature(SafeFileHandle HidDeviceObject, ref Byte lpReportBuffer, Int32 ReportBufferLength);

Declare Function HidD_GetFeature Lib "hid.dll" (ByVal HidDeviceObject As SafeFileHandle, out lpReportBuffer As Byte, ReportBufferLength As Int32) As Boolean

Public Shared Function HidD_GetFeature(hidDeviceObject As SafeFileHandle, ByVal reportBuffer As Byte(), ByVal reportBufferLength As UInt32) As Boolean

            SafeFileHandle HidDeviceObject,

        ByVal HidDeviceObject As SafeFileHandle, _